0102030405
Acetyl Tetrapeptide-40 (≥98%) Cosmetic Grade for Eye Contour Care
01
Product Description
1. Mechanism of Action (MOA)
Acetyl Tetrapeptide-40 is a biomimetic peptide specifically designed to combat the signs of aging and fatigue in the eye contour area. Its mechanism is multi-faceted, targeting both cellular energy metabolism and the dermal-epidermal junction (DEJ):
Cellular Energy Activation:
The peptide acts as a potent activator of cytochrome c oxidase (Complex IV), a key enzyme in the mitochondrial electron transport chain.
By enhancing mitochondrial function and cellular respiration, it boosts ATP production in skin cells, particularly in energy-demanding fibroblasts and keratinocytes in the periorbital area.
This "energy recharge" helps revitalize tired-looking skin, reducing the appearance of fatigue.
Strengthening the Dermal-Epidermal Junction (DEJ):
It stimulates the synthesis and organization of key structural components at the DEJ, particularly Collagen Type IV, VII and Laminin-5.
A stronger and more cohesive DEJ improves skin firmness, reduces sagging (which contributes to under-eye bags), and ensures better nutrient exchange between layers.
Anti-Glycation Activity:
The peptide helps protect proteins like collagen from glycation, a process that leads to Advanced Glycation End-products (AGEs) which cause stiffness, yellowing, and loss of function in the skin.
2. In Vitro Efficacy Data
Mitochondrial Activity: In human fibroblast cultures, Acetyl Tetrapeptide-40 demonstrated a significant, dose-dependent increase in cytochrome c oxidase activity and overall ATP production.
DEJ Protein Synthesis: Immunofluorescence and ELISA assays confirmed a marked upregulation of Collagen IV, VII, and Laminin-5 synthesis in skin model cultures, indicating a direct role in reinforcing the dermal-epidermal interface.
Anti-Glycation: In vitro models showed the peptide's ability to inhibit the formation of AGEs, helping to maintain collagen flexibility and skin clarity.
3. Clinical Results
Study Design: A 56-day, double-blind, placebo-controlled study was conducted with female volunteers (aged 35-60) applying a cream containing 5 ppm of Acetyl Tetrapeptide-40 twice daily on the eye contour.
Key Findings:
Reduction in Under-Eye Puffiness and Bags: Clinical grading and 3D image analysis showed a significant improvement in the smoothness and firmness of the under-eye area, with a measurable reduction in bag prominence.
Diminished Appearance of Dark Circles: The revitalizing effect on skin metabolism and microcirculation led to a visible reduction in the bluish or dark appearance under the eyes.
Improved Radiance and Reduced Fatigue Signs: Over 80% of subjects perceived their eyes as looking more radiant, less tired, and more awake.
Enhanced Firmness: Instrumental measurements confirmed an increase in skin firmness and elasticity around the eye contour.
Safety Profile
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic at recommended use levels. Proven safe for the delicate eye contour area.
Biocompatibility
As a biomimetic peptide, it is well-tolerated by the skin.
Formulation Compatibility
*Highly soluble and stable in aqueous phases. *Compatible with a wide range of cosmetic ingredients, including other peptides, antioxidants, hyaluronic acid, and common emulsion systems. *Stable across a broad pH range (4.0-8.0).
*Ideal for incorporation into eye creams, gels, serums, and patches.
*Ideal for incorporation into eye creams, gels, serums, and patches.
01
Recommended Usage & Dosage
Recommended Concentration: 2 to 10 ppm (0.0002% - 0.001%) of the pure peptide.
Typical Use Level: 5 ppm (0.0005%) is the standard and clinically proven effective concentration.
Suggested Applications:
Primary: All types of eye contour products (creams, gels, serums, patches).
Secondary: Any facial product targeting radiance, firmness, and anti-fatigue.
01
Energetic Revival
Uniquely boosts mitochondrial function and cellular energy (ATP) to combat signs of fatigue and revitalize the eye area.
01
Structural Reinforcement
Strengthens the Dermal-Epidermal Junction (DEJ) by stimulating key structural proteins (Collagen IV, VII, Laminin-5), leading to improved firmness and reduced sagging.
03
Multi-Faceted Anti-Aging
Effectively targets puffiness, dark circles, and loss of firmness through a comprehensive biological approach.
03
Clinically Proven
Visible results in reducing under-eye bags and dark circles, and improving radiance, confirmed in a clinical study.
03
High Potency & Efficiency
Delivers significant effects at very low concentrations (ppm level), offering excellent cost-effectiveness.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available