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Squalene Antioxidant Properties Fight Premature Skin Aging

Products Name Squalene
CAS No 111-02-4
INCI Name Squalene
Specification  Typically ≥98%
Molecular Weight 410.73 g/mol
Chemical Formula C₃₀H₅₀
Appearance Colorless to pale yellow oily liquid.
Solubility Insoluble in water
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    Product Description

    Squalene is a naturally occurring lipophilic triterpene hydrocarbon with the chemical formula C30H50. It is an essential component of human sebum, accounting for approximately 10–15% of the lipid content in healthy skin. Endogenously, squalene is synthesized in the liver and secreted through sebaceous glands to form a protective barrier on the skin surface.
    Cosmetically used squalene is primarily derived from three sources:
    Shark liver oil: The traditional source, where squalene constitutes up to 90% of the oil (extracted from deep-sea sharks such as the dogfish shark). However, this source has faced ethical and environmental controversies due to overfishing.
    Plant-based sources: A sustainable alternative, extracted from olive oil, amaranth seeds, rice bran, and wheat germ. Plant-derived squalene has identical chemical properties to animal-sourced squalene and is widely adopted in modern cosmetic formulations.
    Synthetic squalene: Produced via microbial fermentation (e.g., using yeast strains like Candida utilis) or chemical synthesis, offering a cruelty-free and scalable option for high-volume production.

    In cosmetic formulations, squalene is a clear, odorless, and non-greasy liquid with excellent spreadability. It is compatible with most cosmetic ingredients, including oils, emollients, surfactants, and active compounds, and is stable under typical storage conditions (avoiding prolonged exposure to high temperatures and UV light).

    Benefits

    Thickeners

    Strengthens the skin barrier function

    As a structural analog of human sebum, squalene integrates seamlessly into the skin’s lipid bilayer, replenishing depleted lipids in dry or damaged skin.
    Actives

    Potent antioxidant activity

    Squalene scavenges free radicals generated by UV radiation, pollution, and oxidative stress, which are major causes of premature skin aging.
    Emulsifiers

    Anti-inflammatory and soothing effects

    For sensitive, irritated, or post-procedure skin, squalene modulates the production of pro-inflammatory cytokines.
    Emulsifiers

    Enhances penetration of active ingredients

    Its lipophilic nature allows squalene to act as a penetration enhancer, facilitating the delivery of oil-soluble active ingredients into the deeper layers of the epidermis. This synergistic effect boosts the efficacy of cosmetic actives without causing skin irritation.
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    Use

    In cosmetic formulations, squalene is typically incorporated at a concentration of 0.5–10%, depending on the product type and desired function. 

    Applications

    It is commonly used in facial creams, serums, lotions, and masks.
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    Facial care products

    Moisturizers and creams, serums and essences, facial cleansers, sensitive skin care.
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    Body care products

    Body lotions and oils: Added to body moisturizers to relieve dry, rough skin on elbows, knees, and heels; used in body oils for a non-greasy, glowing finish. Baby care products: Included in baby lotions and ointments because of its gentleness and ability to protect the delicate skin barrier of infants.
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    Sunscreen products

    Added to mineral and chemical sunscreens to improve spreadability and reduce the white cast of mineral sunscreens (e.g., zinc oxide, titanium dioxide). It also enhances UV protection by scavenging free radicals generated by UV exposure, complementing the sunscreen’s function.
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    Hair care products

    Hair serums and conditioners: Applied to dry or damaged hair to reduce frizz, improve manageability, and protect hair from heat styling damage. It coats the hair cuticle without weighing it down, enhancing shine and softness. Scalp care products: Used in scalp serums to soothe dry, itchy scalps and support a healthy scalp environment.
    storage

    Storage

    Store in a closed container at a dry place at room temperature.

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    Animal Testing

    Not animal tested

    vegetarian1

    Vegan

    Does not contain animal-derived components

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    GMO

    No data available

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