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Sh-Oligopeptide-78 Visibly Lift & Firm Skin
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Product Description
I. Mechanism of Action (MOA)
Sh-Oligopeptide-78 is a novel, stabilized biomimetic peptide engineered to target multiple pathways of skin aging and cellular repair. Its primary mechanisms include:
Extracellular Matrix (ECM) Synthesis: Promotes fibroblast activity and significantly increases the production of key structural proteins including collagen I, III, IV, and elastin.
TGF-β Pathway Activation: Modulates the Transforming Growth Factor-beta pathway to enhance tissue repair, regeneration, and dermal remodeling.
Antioxidant Defense: Provides potent protection against oxidative stress by neutralizing free radicals and enhancing the activity of endogenous antioxidant systems.
Cellular Longevity: Supports skin cell vitality and function by activating sirtuin pathways and protecting against telomere shortening.
II. In Vitro Efficacy Data
Collagen Synthesis: Treatment with Sh-Oligopeptide-78 (5-20 µg/mL) increased collagen I synthesis by 245% and elastin production by 198% in human dermal fibroblast cultures.
Antioxidant Activity: Demonstrated significant ROS reduction (94% at 50 µM) in UV-stressed human keratinocytes.
Gene Expression Analysis: Upregulated TIMP-1, TIMP-2, and SIRT-1 expression while inhibiting MMP-1, MMP-3, and MMP-9 activity in 3D skin models.
Cellular Protection: Reduced DNA damage by 82% in oxidative stress models and enhanced cellular longevity markers.
III. Clinical Results
12-Week Anti-Aging Study (n=60, 3% Sh-Oligopeptide-78 formulation):
-47.5% reduction in wrinkle depth (VIA-complex analysis)
+42.3% improvement in skin elasticity (Cutometer®)
+35.8% increase in skin density (ultrasound measurement)
+29.4% improvement in skin hydration (Corneometer®)
94% of subjects showed visible improvement in overall skin youthfulness
16-Week Photoaging Study:
Significant improvement in overall photodamage score (-3.2 points on Griffiths scale)
81% reduction in fine lines appearance
Enhanced skin brightness and texture uniformity
88% of participants reported improved skin firmness and tightness
Safety Profile
*Non-irritating (HRIPT confirmed)
*Non-comedogenic *Ophthalmologist tested *Suitable for all skin types, including sensitive skin
*Non-comedogenic *Ophthalmologist tested *Suitable for all skin types, including sensitive skin
Formulation Compatibility
*Enhanced stability in pH range 4.0-7.5
*Excellent compatibility with vitamins C and E, hyaluronic acid, other peptides
*Thermal stable up to 50°C *Synergistic with antioxidants and growth factors
*Excellent compatibility with vitamins C and E, hyaluronic acid, other peptides
*Thermal stable up to 50°C *Synergistic with antioxidants and growth factors
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Recommended Dosage & Formulations
Effective Concentration: 2-5% in final product
Optimal Formulations:
Anti-aging serums and concentrates
Firming and lifting treatments
Regenerative night creams
Professional skincare treatments
Application: Apply twice daily to cleansed face and neck
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Multi-target Anti-aging Solution
Addresses structural, oxidative, and cellular aspects of skin aging
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Superior Stabilization Technology
Enhanced bioavailability and prolonged activity
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Clinically Proven Efficacy
Demonstrated significant improvements in wrinkles, elasticity, and density
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Comprehensive Skin Rejuvenation
Targets both visible signs of aging and underlying cellular health
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available