0102030405
Pentapeptide-25 Deep Wrinkle Correction & Firming
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Product Description
1. MOA
Pentapeptide-25 is a synthetic peptide designed to combat signs of skin aging through a multi-faceted approach, primarily focusing on enhancing the skin's structural integrity and barrier function.
Extracellular Matrix (ECM) Enhancement:
The peptide acts as a messenger to stimulate dermal fibroblasts, promoting the synthesis of key structural proteins including Collagen I, III, and IV, as well as Elastin.
This leads to a denser, more robust dermal matrix, resulting in improved skin firmness, elasticity, and a reduction in the appearance of wrinkles.
Dermal-Epidermal Junction (DEJ) Reinforcement:
By specifically supporting the production of Collagen IV (a key component of the DEJ), it strengthens the critical connection between the dermis and epidermis.
This results in improved skin cohesion, a lifted appearance, and enhanced nutrient exchange.
Barrier Function Support: It aids in the synthesis of proteins essential for a healthy stratum corneum, helping to improve hydration and skin resilience.
2. In Vitro Efficacy Data
In-vitro studies on human dermal fibroblasts confirm its regenerative potential.
Gene Expression Analysis (qPCR): Demonstrates a significant upregulation of genes encoding for Collagen I (COL1A1), Collagen III (COL3A1), and Elastin (ELN).
Collagen Synthesis Assay: A dose-dependent increase in Collagen I protein production (e.g., >40% increase at 10 ppm) is observed in cell culture models.
Fibroblast Proliferation Assay: Shows a stimulatory effect on fibroblast metabolic activity, indicating enhanced cellular function and tissue repair capacity.
3. Clinical Results
A 12-week clinical study with female volunteers (aged 40-60) using a serum containing 5% Pentapeptide-25 demonstrated significant anti-aging benefits.
Skin Firmness & Elasticity: Instrumental measurements showed a 25% improvement in firmness and a 20% increase in elasticity.
Wrinkle Reduction: Image analysis confirmed a 30% reduction in the average depth of nasolabial folds.
Skin Hydration: A 18% increase in skin hydration levels was recorded via corneometry.
Subject Self-Assessment: 85% of participants reported their skin felt firmer, looked smoother, and had a more youthful overall appearance.
Tolerance: 100% of subjects completed the study with no adverse reactions, confirming excellent skin compatibility.
Safety Profile
Non-irritating, non-sensitizing, and safe for use on all skin types, including sensitive skin.
PH Compatibility
Effective in a pH range of 5.0 - 7.0.
Formulation Compatibility
Synergistic with: Hyaluronic Acid (for hydration), Niacinamide (for barrier support), Antioxidants (Vitamin C, E), and other Peptides. Compatible with: A wide range of emulsion systems, serums, and gels. Incorporation: Add to the water phase at temperatures below 40°C with moderate stirring to ensure complete dissolution and stability.
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Recommended Usage & Dosage
Recommended Usage Level: 4% - 7% in the final formulation.
Suggested Formulations:
Anti-Aging Serums & Concentrates
Firming & Lifting Creams
Night Repair Treatments
Neck & Décolletage Creams
Age-Defying Eye Creams
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Multi-Target Anti-Aging
Uniquely addresses multiple signs of aging by stimulating collagen/elastin synthesis and reinforcing the DEJ.
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Clinically Proven Efficacy
Significantly improves skin firmness, elasticity, and wrinkle appearance in validated clinical studies.
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Barrier-Strengthening Benefits
Offers dual action by supporting both dermal structure and epidermal barrier function.
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Superior Safety Profile
Ideal for long-term use and suitable for all skin types, including mature and sensitive skin.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available