0102030405
Palmitoyl Tetrapeptide-20 (≥95% Purity) Cosmetic Grade
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Product Description
1. Mechanism of Action (MOA)
Palmitoyl Tetrapeptide-20 is a lipopeptide designed to strengthen the skin barrier and improve hydration through biomimetic mechanisms:
Stimulation of Ceramide Synthesis:
Upregulates key enzymes (e.g., serine palmitoyltransferase) involved in the biosynthesis of ceramides, especially Ceramide EOS and Ceramide NP.
Enhances the lamellar structure of the stratum corneum for improved cohesion.
Claudin-4 Modulation:
Promotes the expression of tight junction proteins (e.g., Claudin-4) in the stratum granulosum, reinforcing the epidermal barrier.
Hydration Retention:
Supports natural moisturizing factor (NMF) production and reduces transepidermal water loss (TEWL).
2. In Vitro Efficacy Data
Ceramide Synthesis: 2.5-fold increase in Ceramide EOS and NP levels in human keratinocytes at 10 ppm.
Barrier Gene Expression: 180% upregulation of Claudin-4 mRNA in reconstructed epidermis models.
TEWL Reduction: 35% decrease in TEWL in ex vivo skin models after 48 hours.
Anti-Inflammatory: 40% suppression of IL-1α release in UV-stressed skin equivalents.
3. Clinical Results
Study Design: 28-day, single-blind study on 30 volunteers with dry/sensitive skin using a cream with 50 ppm Palmitoyl Tetrapeptide-20.
Results:
TEWL Reduction: 27% improvement in barrier function.
Hydration: 32% increase in corneometer values.
Smoothness: 25% reduction in roughness by visioscan analysis.
Subject Feedback: 89% reported less tightness and irritation.
Safety
Non-irritating (HRIPT confirmed), non-comedogenic, and suitable for compromised skin.
Compatibility
Stable at pH 5.0–7.0; compatible with niacinamide, ceramides, cholesterol, and fatty acids.
Avoid
Strong ionic surfactants (e.g., SLES) and highly acidic environments (<pH 4.0).
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Recommended Usage & Dosage
Concentration: 20–100 ppm (0.002%–0.01%) in final formulations.
Optimal Dose: 50 ppm for significant barrier repair.
Applicable Products:
Barrier repair creams, sensitive skin formulations, moisturizers, and post-procedure products.
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Barrier-Focused
Targets ceramide synthesis and tight junctions for holistic barrier restoration.
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Rapid Efficacy
Clinically proven to reduce TEWL and improve hydration in 4 weeks.
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Sensitive Skin-Friendly
Validated for use on dry, reactive, and compromised skin.
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Synergistic Potential
Ideal for combining with ceramides and cholesterol in barrier formulations.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available