0102030405
Oligopeptide-3 For Improved Skin Elasticity & Tone
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Product Description
I. Mechanism of Action (MOA)
Oligopeptide-3 is a biomimetic peptide engineered to target multiple pathways of skin aging. Its primary mechanism involves:
Extracellular Matrix Stimulation: Promotes fibroblast activity and increases synthesis of key structural proteins including collagen I, III, and elastin
TGF-β Pathway Activation: Modulates transforming growth factor-beta signaling to enhance tissue repair and remodeling
Antioxidant Protection: Demonstrates free radical scavenging activity, protecting skin cells from oxidative stress
Barrier Function Enhancement: Strengthens stratum corneum integrity through increased ceramide synthesis
II. In Vitro Efficacy Data
Fibroblast Studies: Treatment with Oligopeptide-3 (10-50 µg/mL) increased collagen I synthesis by 187% and elastin production by 156% vs. control in human dermal fibroblast cultures
Antioxidant Activity: Demonstrated significant ROS reduction (89% at 100 µM) in UV-stressed keratinocytes
Gene Expression Analysis: Upregulated TIMP-1 and TIMP-2 expression while inhibiting MMP-1 activity in 3D skin models
Barrier Function: Increased ceramide synthase expression by 67% in reconstructed epidermis models
III. Clinical Results
12-Week Randomized Study (n=45, 2% Oligopeptide-3 formulation):
-41.3% reduction in wrinkle depth
+38.7% improvement in skin elasticity
+32.5% increase in skin hydration
92% of subjects showed visible improvement in skin firmness
16-Week Photoaging Study:
Significant improvement in overall photodamage score
78% reduction in fine lines appearance
Enhanced skin brightness and texture uniformity
Safety Profile
*Non-irritating (HRIPT confirmed) *Non-comedogenic *Ophthalmologist tested *Suitable for sensitive skin
Formulation Compatibility
*PH stable (4.0-7.5) *Compatible with common cosmetic ingredients *Thermal stable up to 45°C *Synergistic with vitamins C and E, hyaluronic acid, other peptides
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Recommended Dosage & Formulations
Effective Concentration: 2-5% in final product
Optimal Formulations:
Anti-aging serums and creams
Firming treatments
Eye contour products
Sheet masks and ampoules
Application: Twice daily on cleansed face and neck
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Multi-target Anti-aging
Addresses structural, oxidative, and barrier aspects of skin aging
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Clinically Proven Efficacy
Demonstrated significant improvements in wrinkles, elasticity, and hydration
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Superior Safety Profile
Suitable for long-term use on all skin types
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Formulation Versatility
Easily incorporated into various cosmetic products
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available