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Myristoyl Pentapeptide-4 Visibly Lift Sagging Skin & Improve Elasticity
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Product Description
1. MOA
Myristoyl Pentapeptide-4 is a biomimetic lipopeptide specifically designed to target loss of skin firmness and elasticity. Its mechanism focuses on revitalizing the dermal matrix through targeted cellular communication.
Fibroblast Activation & ECM Stimulation:
The peptide sequence acts as a messenger to stimulate dermal fibroblasts, promoting increased synthesis of key extracellular matrix (ECM) components.
This leads to enhanced production of Collagen I, III, and Elastin, effectively restoring the structural foundation of the skin for improved firmness and resilience.
Dermal-Epidermal Junction (DEJ) Reinforcement:
Supports the structural integrity of the DEJ by promoting the synthesis of anchoring proteins like Collagen IV and VII.
This creates a stronger foundation between dermis and epidermis, resulting in a lifted and more toned appearance.
Optimized Bioavailability: The myristoyl (C14) lipid chain enhances skin penetration and stability, ensuring effective delivery of the peptide to its target sites in the dermis.
2. In Vitro Efficacy Data
3. Clinical Results
2. In Vitro Efficacy Data
In-vitro studies demonstrate significant matrix-building capabilities:
Gene Expression Analysis: Shows upregulation of collagen-related genes (COL1A1, COL3A1) and elastin gene expression.
Collagen Synthesis Assay: 150% increase in Collagen I production in human fibroblast cultures at 10 ppm concentration.
Fibroblast Proliferation: 35% increase in metabolic activity of dermal fibroblasts, indicating enhanced cellular function.
3. Clinical Results
12-week clinical study with 45 female volunteers (ages 45-65) using a serum containing 5% Myristoyl Pentapeptide-4:
Skin Firmness: 27% improvement in cutometry measurements
Wrinkle Depth: 31% reduction in nasolabial fold depth
Skin Elasticity: 22% improvement in ballistometry measurements
Visual Assessment: 89% of subjects showed visible improvement in skin tightness and contour
Tolerance: 100% of subjects completed the study with no reported irritation
Safety Profile
Non-irritating, non-sensitizing, and suitable for all skin types including sensitive skin
PH Stability
Effective in pH range of 4.5-7.0
Formulation Compatibility
Synergistic Partners: Hyaluronic Acid, Niacinamide, Vitamin C derivatives, Other peptides
Optimal Vehicles: Water-based serums, Emulsions, Gels Temperature Stability: Stable up to 40°C for 3 months
Optimal Vehicles: Water-based serums, Emulsions, Gels Temperature Stability: Stable up to 40°C for 3 months
Incompatibilities
Avoid strong oxidizing/reducing agents
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Recommended Usage & Dosage
Recommended Usage: 3-6% in final formulation
Optimal Formulations:
Firming serums and concentrates
Lifting creams and lotions
Neck and décolletage treatments
Age-defying eye creams
Professional treatment ampoules
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Targeted Firming Action
Specifically designed to address sagging skin through ECM regeneration
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Multi-dimensional Lifting
Improves skin density, elasticity, and structural integrity
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Clinically Validated Efficacy
Proven to reduce wrinkle depth and improve firmness parameters
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Excellent Safety Profile
Suitable for long-term use on all skin types
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available