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Myristoyl Pentapeptide-17 Intensive Wrinkle Smoothing & Firming Treatment
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Product Description
1. MOA
Myristoyl Pentapeptide-17 is a synthetic, biomimetic peptide designed to target the appearance of skin aging by supporting the dermal-epidermal junction (DEJ) and extracellular matrix (ECM).
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Dermal-Epidermal Junction (DEJ) Reinforcement:
The peptide sequence is engineered to mimic the activity of natural proteins that are crucial for the structural integrity of the DEJ.
By signaling dermal cells, it helps to promote the synthesis of key DEJ components such as Collagen IV, Collagen VII, and Laminin V. A robust DEJ is essential for firm, toned skin and effective nutrient exchange.
Extracellular Matrix (ECM) Support:
It provides a supportive signal to fibroblasts, the primary cells responsible for producing the structural scaffold of the skin.
This leads to an increased production of major dermal structural proteins, including Collagen I, III, and Elastin, resulting in improved skin density, elasticity, and a reduction in the appearance of wrinkles.
Enhanced Bioavailability: The myristoyl (C14) lipid chain attached to the peptide enhances its skin penetration and stability, allowing it to effectively reach its target sites within the dermis.
2. In Vitro Efficacy Data
2. In Vitro Efficacy Data
In-vitro studies on human dermal fibroblasts confirm its multi-faceted rejuvenating activity.
Gene Expression Analysis (PCR): Demonstrates a significant upregulation of genes encoding for Collagen I, III, IV, VII, and Laminin 5.
Collagen Protein Synthesis Assay: A dose-dependent increase in the production of Collagen I and III proteins is observed in cell culture, confirming the translation of genetic signals into functional proteins.
Fibroblast Proliferation Assay: Shows a stimulatory effect on fibroblast metabolism and proliferation, enhancing the skin's natural regenerative capacity.
3. Clinical Results
3. Clinical Results
Clinical studies with formulations containing 2-5% Myristoyl Pentapeptide-17 demonstrate significant visual improvements in skin aging signs.
Study Design: 12-week, double-blind, placebo-controlled study with female volunteers aged 40-65, applying a serum containing 4% Myristoyl Pentapeptide-17 twice daily.
Instrumental Results:
Cutometry: A statistically significant improvement in skin elasticity and firmness (up to 18% increase).
Profilometry: A significant reduction in the depth and volume of wrinkles, particularly in the crow's feet area.
Visual & Photographic Assessment:
Clinical Grading: Expert graders noted a visible improvement in overall skin firmness, a lifting effect on facial contours, and a reduction in the appearance of sagging.
Subject Self-Assessment: Over 85% of participants reported their skin felt firmer, looked more lifted, and had a more youthful appearance.
Excellent Tolerance: The ingredient was very well-tolerated, with no reports of irritation, making it suitable for long-term use on all skin types, including sensitive skin.
Safety Profile
It is a non-irritating, non-cytotoxic, and highly biocompatible ingredient.
PH Compatibility
Effective in a wide pH range, ideally between 4.5 and 7.0, compatible with most cosmetic formulations.
Formulation Compatibility
Synergistic with: Other anti-aging actives like Hyaluronic Acid (for hydration), Niacinamide (for barrier support and even tone), Vitamin C derivatives (for antioxidant boost), and other peptides.
Compatible with: A wide range of emulsifiers, thickeners, and preservatives. It is stable in aqueous solutions and oil-in-water emulsions. Handling: As with most peptides, it is recommended to incorporate it into the water phase at low to moderate temperatures (<40°C) to preserve its activity.
Compatible with: A wide range of emulsifiers, thickeners, and preservatives. It is stable in aqueous solutions and oil-in-water emulsions. Handling: As with most peptides, it is recommended to incorporate it into the water phase at low to moderate temperatures (<40°C) to preserve its activity.
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Recommended Usage & Dosage
Recommended Usage Level: 2% - 5% in the final product.
Suggested Formulations:
Serums & Ampoules: For high-potency, targeted treatments.
Firming Creams & Lotions: For daily all-over facial and neck care.
Lifting & Contouring Gels: For focused application on the jawline and décolletage.
Eye Creams: To improve firmness and reduce the appearance of sagging in the delicate eye area.
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Targeted DEJ & ECM Action
Uniquely designed to reinforce the critical dermal-epidermal junction while boosting collagen and elastin for multi-layered skin firming.
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Clinically Proven Lifting Effect
Delivers visible improvements in skin firmness, elasticity, and facial contour, reducing the signs of sagging.
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Biomimetic & Safe
Mimics the body's natural signaling processes, offering a highly biocompatible and non-irritating approach to anti-aging, ideal for sensitive skin.
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Superior Penetration
The myristoyl modification ensures the peptide effectively reaches its target sites within the skin for optimal efficacy.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available