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Myristoyl Pentapeptide-12 Strengthen Skin Barrier & Lock in Hydration
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Product Description
1. MOA
Myristoyl Pentapeptide-12 is a synthetic lipopeptide designed to enhance skin's barrier function and overall conditioning. Its mechanism is multifaceted, focusing on structural support and hydration.
Barrier Function Enhancement:
The peptide sequence is believed to support the synthesis of key structural proteins in the stratum corneum and the dermal-epidermal junction, such as filaggrin and certain collagens.
By reinforcing this natural architecture, it helps to compact the stratum corneum, reduce Transepidermal Water Loss (TEWL), and improve the skin's resilience against environmental aggressors.
Dermal-Epidermal Junction (DEJ) Support:
It provides bio-stimulatory signals to strengthen the DEJ, the critical foundation for firm, youthful-looking skin. This leads to improved skin elasticity and a reduction in the appearance of fine lines.
Enhanced Bioavailability and Emolliency: The myristoyl (C14) lipid chain serves a dual purpose: it improves the skin penetration of the peptide and contributes a luxurious, emollient feel to formulations, aiding in immediate skin softening.
3. Clinical Results
2. In Vitro Efficacy Data
In-vitro studies demonstrate its efficacy in supporting skin's structural integrity.
Gene Expression Analysis (PCR): Shows upregulation of genes associated with barrier proteins (e.g., Filaggrin) and dermal structural proteins (e.g., Collagen I, IV).
Collagen Synthesis Assay (Human Fibroblasts): A statistically significant, dose-dependent increase in the production of Collagen I is observed, confirming its role in supporting the skin's extracellular matrix.
TEWL Reduction Model (Reconstructed Human Epidermis): Demonstrates an improved barrier function and reduced water loss in tissue models subjected to stress.
3. Clinical Results
Clinical evaluations of formulations containing 3-5% Myristoyl Pentapeptide-12 confirm its skin-conditioning benefits.
Study Design: 8-week, single-blind study with volunteers exhibiting dry and sensitive skin, using a cream with 4% Myristoyl Pentapeptide-12 twice daily.
Instrumental Results:
Corneometry: A significant increase in skin hydration levels was measured after 2 weeks, with continued improvement.
TEWL Measurement: A notable reduction in transepidermal water loss was observed, indicating a stronger, more resilient skin barrier.
Cutometry: Improvement in skin elasticity parameters was recorded.
Visual & Self-Assessment:
Clinical Grading: Dermatological assessment showed a visible reduction in dryness, flakiness, and roughness.
Subject Feedback: Over 80% of participants reported that their skin felt softer, smoother, and less reactive to environmental triggers.
Tolerance: Excellent. The ingredient was well-tolerated by all subjects, including those with self-assessed sensitive skin.
Safety Profile
It is non-irritating, non-comedogenic, and highly safe for topical use.
PH Compatibility
Effective in a broad pH range (4.5 - 7.0), making it highly versatile for various formulations.
Formulation Compatibility
Synergistic with: Other barrier-supporting ingredients like Ceramides, Niacinamide, Cholesterol, and Hyaluronic Acid. This combination creates a powerful "barrier repair complex."
Compatible with: A wide range of oils, emulsifiers, and other peptides. Its lipid chain integrates well into emulsion systems. Incorporation: Recommended to add to the water phase at low temperatures (<40°C) with moderate stirring to ensure complete dissolution and preserve activity.
Compatible with: A wide range of oils, emulsifiers, and other peptides. Its lipid chain integrates well into emulsion systems. Incorporation: Recommended to add to the water phase at low temperatures (<40°C) with moderate stirring to ensure complete dissolution and preserve activity.
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Recommended Usage & Dosage
Recommended Usage Level: 3% - 5% in the final product.
Suggested Formulations:
Barrier Repair Creams & Lotions: Ideal for daily use to maintain and protect a healthy skin barrier.
Rich Moisturizers: For intense hydration and conditioning of dry and very dry skin.
Sensitive Skin Serums: As a core soothing and strengthening active.
Pre- and Post-Procedure Care: To support skin recovery by enhancing barrier function.
Luxurious Face Oils & Serums: Contributing both efficacy and an elegant skin feel.
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Barrier-Focused Bio-Active
Specifically designed to strengthen the skin's natural barrier, leading to improved hydration, resilience, and overall skin health.
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Dual-Action Technology
Combines the bio-stimulatory properties of a peptide with the emollient and penetration-enhancing benefits of a lipid chain.
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Clinically Proven Hydration & Comfort
Significantly increases skin moisture, reduces TEWL, and alleviates feelings of dryness and tightness.
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Ideal for Sensitive Skin
Its gentle, non-irritating nature and barrier-strengthening action make it a cornerstone ingredient for sensitive and reactive skin formulations.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available