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Dipetide Diaminobutyroyl Benzylamide Diacetate A Comprehensive Review of Its Cosmetic Properties
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Product Description
1. MOA
Acetyl Dipeptide-1 Cetyl Ester is a renowned synthetic peptide that acts as a topical alternative to injectable neurotoxins (e.g., Botox). Its mechanism is designed to reduce the appearance of expression lines by modulating neuromuscular signals.
Inhibition of Acetylcholine Release: The peptide functions by competitively inhibiting the interaction between the SNARE protein complex and acetylcholine-containing vesicles in the presynaptic nerve terminals. This leads to a partial and reversible reduction in the release of the neurotransmitter acetylcholine into the neuromuscular junction.
Reduction of Muscle Contractions: With less acetylcholine signaling, the subsequent contraction of the underlying facial muscles (e.g., those responsible for frown lines, crow's feet) is softened and relaxed.
Reversible & Non-Toxic Action: Unlike injectable neurotoxins, this peptide does not cause permanent proteolysis of SNARE proteins. Its effect is temporary and reversible, making it a safe cosmetic ingredient for long-term use. The cetyl ester group enhances its skin penetration.
2. In Vitro Efficacy Data
SNARE Complex Inhibition: In vitro models using neuronal cell lines demonstrated that Acetyl Dipeptide-1 Cetyl Ester effectively interferes with the SNARE complex assembly, leading to a dose-dependent reduction in acetylcholine release.
Muscle Contraction Reduction: Studies on engineered human skin models showed a significant decrease in the frequency and intensity of muscle fiber contractions upon treatment with the peptide.
3. Clinical Results
Clinical studies on human volunteers confirm its efficacy in reducing the depth and appearance of dynamic wrinkles.
Wrinkle Depth Reduction: In a 28-day double-blind clinical study, a formulation containing 10% of a solution with Acetyl Dipeptide-1 Cetyl Ester (corresponding to ~5 ppm of the pure peptide) applied twice daily led to a significant reduction in the depth of crow's feet wrinkles by up to 27%, as measured by skin replicas and image analysis.
Improvement in Wrinkle Severity: Expert grading showed a noticeable improvement in the Global Wrinkle Score, with effects observed as early as 15-30 days.
High Consumer Satisfaction: A vast majority of participants reported a visible smoothing of their expression lines and a more relaxed, youthful appearance.
Safety Profile
Acetyl Dipeptide-1 Cetyl Ester has an excellent safety profile for topical use. It is non-irritating, non-sensitizing, and specifically designed to act locally without systemic effects. It does not carry the risks associated with injectable neurotoxins.
Compatibility
Synergistic Combinations:
*Other Peptides (e.g., Palmitoyl Tripeptide-38, Acetyl Octapeptide-3): For a multi-targeted approach to relax muscles and boost collagen. *Hyaluronic Acid & Moisturizers: To plump the skin and smooth out surface lines.
*Antioxidants (Vitamin C, E): To provide protection against environmental aging factors. *Skin Barrier Lipids (Ceramides): To support overall skin health.
Formulation Stability: It is stable in a wide pH range (4.0-8.0) and can be incorporated into various emulsions, serums, and gels.
*Other Peptides (e.g., Palmitoyl Tripeptide-38, Acetyl Octapeptide-3): For a multi-targeted approach to relax muscles and boost collagen. *Hyaluronic Acid & Moisturizers: To plump the skin and smooth out surface lines.
*Antioxidants (Vitamin C, E): To provide protection against environmental aging factors. *Skin Barrier Lipids (Ceramides): To support overall skin health.
Formulation Stability: It is stable in a wide pH range (4.0-8.0) and can be incorporated into various emulsions, serums, and gels.
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Recommended Dosage & Formulations
Recommended Usage Level: 2 - 10 ppm (0.0002% - 0.001%) of the pure peptide. It is extremely potent even at very low concentrations.
Suitable Formulations: Its efficacy makes it ideal for targeted anti-aging products.
Anti-Wrinkle Serums & Concentrates
Eye Contour Creams & Gels
Moisturizers and Day/Night Creams
Targeted "Botox-like" Treatment Products
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Topical Botox-Like Alternative
Offers a non-invasive, needle-free solution to reduce the appearance of expression lines by mimicking the mechanism of injectable neurotoxins.
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Clinically Proven Efficacy
Supported by clinical data showing a significant reduction in wrinkle depth, particularly in the crow's feet area.
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Safe & Reversible Action
Provides a temporary and reversible muscle-relaxing effect, ensuring high safety for continuous cosmetic use.
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High Potency
Effective at part-per-million (ppm) concentrations, offering excellent cost-effectiveness for formulations.
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Strong Consumer Appeal
The "Botox in a jar" or "needle-free solution" concept is a powerful and highly marketable claim that resonates strongly with consumers seeking clinical-level results without injections.
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Penetration Enhanced
The cetyl ester group ensures effective delivery of the peptide to its target site of action.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available