0102030405
Copper Tripeptide-1 Wound Healing & Anti-Aging Peptide
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Product Description
1. Mechanism of Action (MOA)
Copper Tripeptide-1 (GHK-Cu) is a naturally occurring copper-binding peptide that plays a fundamental role in tissue repair and regeneration through multiple pathways:
Extracellular Matrix Remodeling:
Upregulates synthesis of key structural proteins including collagen I, III, IV, elastin, and glycosaminoglycans.
Modulates matrix metalloproteinases (MMPs) to promote balanced tissue remodeling - inhibiting MMP-1 while activating MMP-2 for organized collagen deposition.
Stem Cell Activation & Cellular Communication:
Attracts immune cells and fibroblasts to wound sites, enhancing tissue repair.
Promotes the differentiation of mesenchymal stem cells and stimulates angiogenesis.
Anti-Inflammatory & Antioxidant Effects:
Suppresses reactive oxygen species and reduces inflammatory cytokines like TNF-α.
Upregulates antioxidant enzymes including superoxide dismutase and metallothionein.
2. In Vitro Efficacy Data
Collagen Synthesis: 2.8-fold increase in collagen production in human fibroblast cultures at 1 μM.
Gene Expression: Upregulation of 31 genes involved in tissue repair and anti-oxidation.
MMP Modulation: 60% inhibition of MMP-1 (collagenase) while increasing MMP-2 (gelatinase) activity for proper matrix remodeling.
Cell Migration: 3.5-fold enhancement of fibroblast migration in scratch wound assays.
3. Clinical Results
3. Clinical Results
Study Design: Multiple clinical trials including a 12-week study on 60 volunteers (40-65 years) using a serum with 5 ppm Copper Tripeptide-1.
Results:
Wrinkle Reduction: 35% improvement in fine lines and wrinkles by visioanalysis.
Firmness & Elasticity: 18% increase in cutometer measurements.
Skin Texture: 42% improvement in skin smoothness and roughness.
Barrier Function: 25% reduction in TEWL and enhanced hydration.
Wound Healing: Accelerated recovery in post-procedure applications.
Safety
Excellent safety profile with over 30 years of clinical use. Non-irritating, non-sensitizing, suitable for sensitive skin.
Compatibility
Stable in pH 5.0-7.5; compatible with most cosmetic ingredients except:
Strong chelating agents (EDTA) High concentrations of other metals Strong reducing agents
Strong chelating agents (EDTA) High concentrations of other metals Strong reducing agents
Formulation Tips
Protect from light and oxidation. Ideal for aqueous systems and emulsions.
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Recommended Usage & Dosage
Concentration: 1-10 ppm (0.0001%-0.001%) in final formulations.
Optimal Dose: 5 ppm for clinically proven regenerative effects.
Applicable Products:
Anti-aging serums and creams
Wound healing formulations
Post-procedure treatments
Hair growth products
Scar reduction formulations
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Multi-Target Regeneration
Addresses skin aging through comprehensive matrix remodeling.
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Clinically Proven
Extensive clinical data supporting efficacy in both wound healing and anti-aging.
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Natural Biomimetic
Mimics the body's own repair mechanisms.
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Low Concentration Efficacy
Powerful effects at parts-per-million levels.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available