0102030405
Collagen Boosting Serum With Nonapeptide-1
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Product Description
1. Mechanism of Action (MOA)
Nonapeptide-1 is a biomimetic signaling peptide that functions as a matrikine. It is a fragment of Type I Collagen, designed to actively combat skin aging by stimulating the synthesis of key structural components in the dermal extracellular matrix (ECM).
Targeted Pathway: It specifically targets and activates Fibroblast Cells.
Primary Action: Through its interaction with specific cell surface receptors, Nonapeptide-1 sends a "repair signal" to the fibroblasts, prompting them to:
-Upregulate Collagen Synthesis: Significantly increase the production of Collagen Type I and Type III, the most abundant collagens in the skin, which are crucial for skin strength, firmness, and resilience.
-Stimulate Other ECM Components: Enhance the synthesis of other vital matrix proteins, such as Fibronectin, which acts as a scaffolding for cell adhesion and tissue repair.
Outcome: By boosting the fundamental "building blocks" of the skin, Nonapeptide-1 effectively re-densifies the dermis, leading to visibly smoother, firmer skin with reduced depth of wrinkles.
2. In Vitro Efficacy Data
Study on Human Dermal Fibroblasts:
Collagen I Synthesis: Treatment with Nonapeptide-1 resulted in a dose-dependent stimulation of Collagen I production. At a concentration of 5 ppm, a >100% increase in Collagen I synthesis was observed compared to untreated cells.
Collagen IV Synthesis: A significant increase in Collagen IV, a key component of the basement membrane, was also noted, improving the dermal-epidermal junction.
Fibronectin Synthesis: A 65% increase in Fibronectin production was demonstrated, confirming its role in reinforcing the dermal matrix structure.
3. Clinical Results
*A 2-month, double-blind, placebo-controlled clinical study on female volunteers with photo-aged skin, using a cream containing a peptide complex including Nonapeptide-1.*
Instrumental Analysis (Skin Replicas):
Wrinkle Reduction: After 2 months of application, a significant reduction in wrinkle depth and volume was measured. Specifically, a -32% reduction in average wrinkle depth was recorded in the crow's feet area.
Skin Smoothness: A marked improvement in skin roughness and smoothness was observed.
Visual Assessment:
Dermatologist grading confirmed a visible improvement in overall skin firmness, elasticity, and a reduction in the appearance of fine lines.
Self-Assessment:
Over 85% of participants agreed that their skin felt firmer and looked smoother and more youthful.
Safety Profile
*Exceptionally safe and well-tolerated. Proven to be non-irritating and non-sensitizing in human repeat insult patch tests (HRIPT).
*Suitable for all skin types, including sensitive skin.
*Composed of natural amino acids, making it biocompatible.
*Suitable for all skin types, including sensitive skin.
*Composed of natural amino acids, making it biocompatible.
Formulation Compatibility
*Excellent stability in aqueous formulations across a wide pH range (4.0 - 8.0).
*Highly soluble in water, making it easy to incorporate into a variety of product types. *Displays excellent synergy with other anti-aging actives, particularly: Palmitoyl Tetrapeptide-7 (the other component of Matrixyl™ 3000) for enhanced anti-inflammatory and synergistic firming effects. Hyaluronic Acid for combined wrinkle-filling and hydration. Other Peptides (e.g., Acetyl Hexapeptide-8) for a multi-mechanism approach. Antioxidants like Vitamin C and E.
*Highly soluble in water, making it easy to incorporate into a variety of product types. *Displays excellent synergy with other anti-aging actives, particularly: Palmitoyl Tetrapeptide-7 (the other component of Matrixyl™ 3000) for enhanced anti-inflammatory and synergistic firming effects. Hyaluronic Acid for combined wrinkle-filling and hydration. Other Peptides (e.g., Acetyl Hexapeptide-8) for a multi-mechanism approach. Antioxidants like Vitamin C and E.
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Recommended Usage & Formulation
Recommended Concentration:
3% - 8% in the final product.
For optimal results comparable to clinical studies, a concentration of 4% - 8% of a complex containing Nonapeptide-1 (e.g., Matrixyl™ 3000) is recommended.
Suitable Formulations:
Anti-Aging & Anti-Wrinkle Serums and Creams
Firming and Lifting Treatments
Daily Moisturizers
Eye Contour Products
Rejuvenating Face Masks
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Proven Collagen Booster
Directly and significantly stimulates the production of Collagen I, III, and Fibronectin to rebuild the skin's structural foundation.
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Clinically Validated Efficacy
Delivers measurable and visible results, with studies showing over 30% reduction in wrinkle depth.
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Safe & Synergistic
Excellent safety profile and works harmoniously with other actives to create powerful, multi-targeted anti-aging solutions.
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Powerful "Repair" Narrative
The "matrikine" or "signal-to-repair" story is scientifically sound and easily communicated to consumers seeking to combat intrinsic aging.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available