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Caprooyl Tetrapeptide-3 High Purity Cosmetic Peptide
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Product Description
1. Mechanism of Action
Caprooyl Tetrapeptide-3 is a synthetic, lipopeptide biomimetic that functions through multiple pathways to combat the signs of skin aging, primarily by promoting a firmer, more lifted appearance.
Eyelid Toning & Firming (Primary MOA):
The peptide's core sequence is designed to mimic the natural effects of γ-aminobutyric acid (GABA), a key inhibitory neurotransmitter.
It modulates the excessive neuronal signals that lead to involuntary micro-contractions of the eyelid and facial muscles.
By reducing this hypertonicity, it helps relax tension, which over time can soften the appearance of fine lines and crow's feet caused by constant muscle activity. This relaxation contributes to a visible "lifting" and firming effect, especially in the delicate eye area.
Dermo-Structural Improvement:
The peptide sequence also supports the dermal extracellular matrix.
It has been shown to upregulate the expression of key structural proteins such as Collagen Type I, III, and IV, and Laminin.
This leads to improved skin density, elasticity, and overall firmness, providing structural support from within.
2. In Vitro Efficacy Data
Collagen & Laminin Synthesis: In human fibroblast cultures, Caprooyl Tetrapeptide-3 demonstrated a significant, dose-dependent increase in the production of Collagen Type I, III, and IV, as well as Laminin. At specific concentrations, increases of over 150% compared to untreated controls were observed.
Gene Expression Analysis: RT-PCR analysis confirmed the upregulation of genes encoding for these structural proteins, validating its bio-stimulant activity at the transcriptional level.
Mechanistic Studies: Binding and receptor studies support its GABA-mimetic activity, confirming its targeted mechanism for muscle relaxation and firming.
3. Clinical Results
Study Design: A 56-day, double-blind, placebo-controlled clinical study was conducted with female volunteers (aged 40-65) applying a formulation containing 5 ppm of Caprooyl Tetrapeptide-3 twice daily on the eye contour and face.
Key Findings:
Eyelid Firmness & Lift: Instrumental measurement (cutometry) showed a 15% improvement in eyelid firmness and a visible reduction in drooping, giving a more "open-eyed" appearance.
Reduction in Wrinkles & Crow's Feet: Image analysis revealed a significant reduction in the depth and volume of wrinkles in the crow's feet area.
Improved Skin Quality: Subjects reported and clinical grading confirmed improvements in skin tightness, smoothness, and overall radiance.
High Consumer Perception: Over 85% of participants perceived a visible lifting effect and agreed that their skin looked firmer and more toned.
Safety Profile
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic at recommended use levels. Compatible with sensitive skin.
Biocompatibility
As a biomimetic peptide, it is well-tolerated by the skin.
Formulation Compatibility
*Highly soluble and stable in aqueous phases. *Compatible with a wide range of cosmetic ingredients, including other peptides, vitamins, hyaluronic acid, and plant extracts. *Stable across a broad pH range (4.0 - 8.0) and under standard formulation conditions.
* Can be incorporated into various emulsions (O/W, W/O), serums, gels, and patches.
* Can be incorporated into various emulsions (O/W, W/O), serums, gels, and patches.
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Recommended Usage & Dosage
Recommended Concentration: 2 to 10 ppm (0.0002% - 0.001%).
Note: This is an extremely low and effective dosage, characteristic of high-performance signal peptides.
Typical Use Level: 5 ppm (0.0005%) is widely used in clinical studies and commercial formulations for significant effects.
Suggested Applications:
Primary: Eye creams, eye serums, eye contour gels/patches.
Secondary: Anti-aging serums, firming creams, neck creams, and overall lifting treatments for the face.
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Dual-Action Technology
Uniquely combines GABA-mimetic muscle relaxation with dermal matrix stimulation for comprehensive anti-aging.
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Proven Eyelid Lift & Firming
Clinically proven to visibly firm eyelids, reduce drooping, and create a more youthful, "awake" look.
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Reduces Signs of Fatigue
Effectively softens crow's feet and fine lines caused by muscle contractions and loss of skin elasticity.
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Extremely Potent & Efficient
Delivers remarkable results at very low concentrations (ppm level), offering high cost-in-use efficiency.
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Science-Backed & Clinically Tested
Supported by robust in-vitro data and a double-blind clinical study.
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Safe & Versatile
Excellent safety profile and easy to formulate into a wide array of premium skincare products.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available