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Arginine Lysine Polypeptide Deep Haircare
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Product Description
1. Mechanism of Action (MOA)
Arginine/Lysine Polypeptide is a synthetic peptide bio-inspired by the venom of cone snails. Its mechanism is highly specific and potent, acting as a neuromuscular blocking agent.
Target: It specifically targets and acts as an antagonist of the post-synaptic nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction.
Process: In normal muscle contraction, the neurotransmitter acetylcholine (ACh) binds to nAChRs, triggering a signal that causes the muscle to contract.
Action: This peptide competitively blocks ACh from binding to the receptor.
Outcome: By inhibiting the signal transmission, it induces a localized and temporary relaxation of facial muscles. This reduction in muscle contraction leads to a visible softening of dynamic expression lines and wrinkles, such as crow's feet and forehead lines, resulting in a smoother skin appearance.
2. In Vitro Efficacy Data
Receptor Binding Assay:
Studies demonstrate that Arginine/Lysine Polypeptide has a high binding affinity for the human nicotinic Acetylcholine Receptor (nAChR).
It exhibits dose-dependent inhibition of acetylcholine-induced receptor activation in cellular models, confirming its potent neuromuscular blocking activity.
Tissue Model Studies:
In ex vivo models using neuromuscular tissue, application of the peptide led to a significant reduction in the frequency and force of muscle contractions.
3. Clinical Results
*A 4-week, double-blind, placebo-controlled clinical study was conducted on female volunteers to evaluate the efficacy of a serum containing Arginine/Lysine Polypeptide on crow's feet.*
Instrumental Analysis (Skin Replicas):
Wrinkle Depth & Volume: After 28 days of twice-daily application, a -30% reduction in the average depth of wrinkles was measured in the treatment group compared to placebo.
Skin Smoothness: A significant improvement in skin surface roughness was observed.
Expert Dermatological Assessment:
A visible reduction in the severity of expression lines was noted as early as 14 days, with continued improvement over the study period.
Self-Assessment Questionnaires:
Over 83% of participants agreed that their skin looked smoother and their expression lines were less noticeable.
78% reported a perceived "relaxed" and "fresher" look in their eye area.
Safety Profile
*Designed for topical use and formulated to act locally without systemic absorption at recommended doses.
*Non-irritating in standard human repeat insult patch tests (HRIPT) when used in approved concentrations.
*However, due to its potent biological activity, it is crucial to adhere to recommended usage levels.
*Non-irritating in standard human repeat insult patch tests (HRIPT) when used in approved concentrations.
*However, due to its potent biological activity, it is crucial to adhere to recommended usage levels.
Formulation Compatibility
*Highly soluble and stable in aqueous formulations.
*Compatible with a wide range of cosmetic ingredients, including other peptides, humectants, and emollients.
*Stable within a pH range of 4.0 - 7.5.
*Ideal for incorporation into targeted serums, creams, and gels for the face and eye area.
*Compatible with a wide range of cosmetic ingredients, including other peptides, humectants, and emollients.
*Stable within a pH range of 4.0 - 7.5.
*Ideal for incorporation into targeted serums, creams, and gels for the face and eye area.
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Recommended Usage & Formulation
Recommended Concentration:
1% - 4% in the final product.
A concentration of 2% is typically effective for noticeable results. Formulators should start at the lower end of the range and conduct efficacy tests.
Suitable Formulations:
Targeted Anti-Wrinkle Serums
Eye Contour Creams & Gels
Intensive Expression Line Treatments
Pre-Makeup Primers
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Potent & Targeted Mechanism
Directly blocks the acetylcholine receptor at the neuromuscular junction, the source of dynamic wrinkles.
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Clinically Proven Efficacy
Shows significant reduction in wrinkle depth (up to -30%) in controlled clinical studies.
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Inspired by Nature
The "cone snail venom" story is scientifically compelling and captures consumer interest in innovative bio-inspired ingredients.
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Fast-Acting Results
Visible improvements can be observed within weeks, offering a rapid response to wrinkle concerns.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available