0102030405
Anti-Aging Concentrate With Acetyl Pentapeptide-1
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Product Description
1. MOA
Acetyl Pentapeptide-1 is a synthetic peptide designed to combat skin aging through targeted extracellular matrix (ECM) stimulation and collagen biosynthesis.
Fibroblast Activation & Collagen Synthesis:
Functions as a signaling molecule to activate dermal fibroblasts through specific receptor interactions
Promotes synthesis of key structural proteins including Collagen I, III, and IV
Enhances production of glycosaminoglycans (GAGs) for improved skin hydration and volume
TGF-β Pathway Modulation:
Modulates Transforming Growth Factor-beta (TGF-β) signaling pathway
Upregulates Smad protein phosphorylation for enhanced collagen gene expression
Optimizes natural tissue repair and regeneration processes
Matrix Protection:
Inhibits matrix metalloproteinase (MMP) activity
Protects existing collagen from enzymatic degradation
Maintains structural integrity of the dermal ECM
2. In Vitro Efficacy Data
In-vitro studies demonstrate significant collagen-stimulating activity:
Collagen Synthesis Assay: 145% increase in Collagen I production in human fibroblast cultures at 50 ppm
Gene Expression Analysis: 2.8-fold upregulation of COL1A1 gene expression
Fibroblast Proliferation: 38% increase in metabolic activity
MMP-1 Inhibition: 67% reduction in collagenase activity
Elastin Production: 42% enhancement in elastin synthesis
3. Clinical Results
12-week clinical study with 48 female volunteers (ages 40-65) using a serum containing 5% Acetyl Pentapeptide-1:
Wrinkle Depth: 34% reduction in nasolabial fold depth (3D skin analysis)
Skin Firmness: 29% improvement in cutometry measurements
Skin Elasticity: 26% enhancement in ballistometry parameters
Skin Density: 31% increase in ultrasound measurements
Hydration Levels: 24% improvement in corneometry
Visual Assessment: 94% of subjects showed visible improvement in skin texture
Subject Satisfaction: 89% reported significant improvement in overall skin appearance
Safety Profile
Non-irritating (0/25 subjects in HRIPT), non-comedogenic
PH Stability
Effective in pH range of 4.5-6.5
Thermal Stability
Stable at temperatures up to 45°C for 3 months
Formulation Compatibility
Synergistic Combinations: Hyaluronic acid, Niacinamide, Vitamin C derivatives Optimal Vehicles: Water-based serums, O/W emulsions, Hydrogels Recommended Partners: Other anti-aging peptides, Growth factors, Antioxidants
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Recommended Usage & Dosage
Recommended Usage: 3-6% in final formulation
Optimal Formulations:
Anti-aging serums and concentrates
Firming and lifting creams
Professional treatment ampoules
Neck and décolletage treatments
Age-defying eye creams
Overnight repair formulations
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Potent Collagen Stimulation
Significant increase in collagen production confirmed by in-vitro and clinical studies
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Multi-dimensional Anti-aging
Addresses wrinkles, firmness, elasticity, and density simultaneously
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Clinically Validated Efficacy
Proven to reduce wrinkle depth by 34% and improve firmness by 29%
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Dual Action Mechanism
Combines collagen synthesis stimulation with matrix protection
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available